Combinatorial optimisation algorithms are central to addressing problems in which the goal is to select an optimal solution from a finite set of alternatives. These algorithms have evolved ...

This study presents SynaptoGen, a differentiable extension of connectome models that links gene expression, protein-protein interaction probabilities, synaptic multiplicity, and synaptic weights, and ...

This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...