The recent withdrawal of rofecoxib (Vioxx) from the market has intensified controversy about the safety of cyclooxygenase (COX)-2 inhibitors. Results from several recently published studies address ...

Aspirin was introduced into clinical medicine in 1899 and its anti-inflammatory, analgesic and antipyretic properties were accompanied by the onset of gastrointestinal and renal toxicity. Over the ...

Cyclooxygenase-2 (COX-2) inhibitors have long been employed to modulate inflammatory responses in a range of conditions, from arthritis to malignancies. In recent years, the convergence of ...

Although all authors completed the disclosure declaration, the following author(s) indicated a financial or other interest that is relevant to the subject matter under consideration in this article.

Ferroptosis plays an essential role in chronic liver diseases, and cyclooxygenase-2 (COX-2) affects liver fibrosis through multiple mechanisms. However, research on COX-2 regulation of ferroptosis in ...

LONDON, Feb 9 (Reuters) - A new arthritis drug causes fewer stomach disorders and complications than older painkillers, researchers said on Friday. They analysed the results of three clinical trials ...