A new study overthrows a long-held theory on how HIV finds its way into host cells. Rather than fusing directly with the host cell membrane, the virus is first engulfed by it to form a vesicle that ...
The entry of HIV-1 into host cells is mediated by precise interactions between viral envelope glycoproteins and cellular receptors. Fusion inhibitors, which disrupt these interactions—particularly by ...
At the cellular level, HIV-1 transmission involves a highly coordinated process whereby the virus binds to CD4 receptors and one of two coreceptors—CCR5 (R5) or CXCR4 (X4)—on host immune cells, ...
The process of brain cell fusion has been recently implicated in the progression of central nervous system (CNS) viral diseases. This novel biological understanding has opened up a new field of ...
Evidence shows almost zero risk of sexual transmission when HIV viral loads are less than 1000 copies/mL, which could allow providers to destigmatize HIV and promote antiretroviral therapy adherence.
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