Reviewed by Yolanda Smith, B.Pharm. Although supercritical fluids were used as eluents for chromatographic separations in 1962, the term supercritical fluid chromatography (SFC) was first used only ...
Supercritical fluids show certain properties that are used to advantage in chromatographic separations: No liquid/gas phase boundary and therefore no surface tension Solute solubility increases with ...
High-performance liquid chromatography (HPLC) for enantiomeric separation of chiral active pharmaceutical ingredients took the drug industry by storm in the late 1990s. Drug companies needed a ...
IN THE WORLD of pharmaceutical drug discovery, where it can take hundreds of millions of dollars to fully develop a drug candidate, finding a streamlined chemical reaction or processing technique that ...
Supercritical Fluid Chromatography (SFC) techniques represent an evolving analytical separation method that harnesses the unique properties of supercritical fluids—predominantly carbon dioxide—to ...
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