During organismal development, homeostasis, and disease, Dishevelled (Dvl) proteins act as key signaling factors in beta-catenin–dependent and beta-catenin–independent Wnt pathways. While their ...
The canonical Wnt signaling pathway. The left panel (A) demonstrates the activated Wnt signaling cascade, while the right side portrays the inhibited Wnt signaling cascade. Wnt binds to the Fz ...
The noncanonical Wnt/PCP pathway. The binding of Wnt ligands leads to the phosphorylation of Dvl, which recruits Invs, Par6, and Smurf. Smurf ubiquitinates the inhibitory protein Prickle, targeting it ...
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