Researchers have uncovered how specific DNA rearrangements called inverted triplications contribute to the development of various genetic diseases. The study reveals that during DNA repair, segments ...

Soft tissue tumours and lesions characterized by USP6 gene rearrangements represent a heterogeneous group of neoplasms that include nodular fasciitis, aneurysmal bone cysts, cellular fibroma of tendon ...

This figure depicts how bridge recombinases have a dual targeting capability that enable these systems to insert new genetic material, delete unwanted regions, or flip existing DNA segments all in a ...

Genomic disorders occur when there are changes or mutations in DNA that disrupt normal biological functions. These can lead to a range of health issues, including developmental delays and neurological ...

Standard laboratory tests can fail to detect many disease-causing DNA changes. Now, a novel 3D chromosome mapping method can reliably reveal these hidden structural variants and lead to new ...

Publication shows that OGM can resolve translocation partners involving MYC in multiple myeloma (MM) more effectively than current methods The release of compelling data in MM underscores the ...

An arms race is unfolding in our cells: Transposons, also known as jumping genes or mobile genetic elements as they can replicate and reinsert themselves in the genome, threaten the cell's genome ...

Phase II safety and preliminary efficacy of amulirafusp alfa (IMM0306) in combination with lenalidomide in patients with relapsed or refractory CD20-positive follicular lymphoma. A phase I study of ...

The advent of CRISPR-Cas has transformed genome editing, but it remains limited by delivery challenges and off-target effects, leading to the development of improved tools, such as base and prime ...

Researchers at the Pacific Northwest Research Institute (PNRI) and collaborating institutions have made a groundbreaking discovery that could significantly advance our understanding of genomic ...