Researchers conducted a study to assess the safety and efficacy of aminoglycosides or polymyxin monotherapy for the treatment of adults with complicated urinary tract infections caused by extensively ...

Am J Health Syst Pharm. 2011;68(17):1607-1614. The trials described herein have several limitations, such as small sample size, the majority of subjects being male, insufficient detail in the ...

The antimalarial drug mefloquine could help treat genetic diseases such as cystic fibrosis, Duchenne muscular dystrophy, as well as some cancers. In these diseases, a mutation in the genetic code ...

Aminoglycoside antibiotics, long established as potent agents against a range of gram-negative and gram-positive bacteria, act primarily by binding to the bacterial ribosome and interfering with ...

Kidney Failure Risk, Ammonia Excretion Linked These factors include a history of heart failure, which was associated with 3-fold increased odds of acute kidney injury. A history of heart failure is ...

Enzymatic drug modification is the most common type of aminoglycoside resistance, but the molecular mechanisms involved in inducing resistance are not yet clear. A new study by Jia et al. identified a ...

The spread of antibiotic resistance, where infectious bacteria are able to defeat the drugs intended to kill them, may not be primarily driven by antibiotic consumption, according to a new study. The ...

Choosing the appropriate antibiotics to treat bacterial infections has grown more challenging because of the emergence of antibiotic-resistant bacteria. Aminoglycosides, as broad-spectrum antibiotics, ...

This cartoon shows the newly identified mefloquine binding site causing the changes in the ribosome's dynamics which promote read-through of the premature stop codons. The main interactions are shown ...

A fluorinated analogue of the naturally occurring aminoglycoside neomycin – well known as an over-the-counter ointment for minor skin abrasions – could lead to a range of much-needed antibiotics in ...